Caracterización histopatológica de los tumores genitales, con énfasis en el tumor venéreo transmisible en la especie canina en el este de Argelia
Resumen
Este estudio tuvo como objetivo proporcionar datos sobre tumores genitales en caninos en el Centro Hospitalario Universitario Ibn Badis de Constantina, centrándose en la localización tumoral y los tipos histológicos en el este de Argelia. El tumor venéreo transmisible, también conocido como sarcoma de Sticker, es un cáncer significativo en los perros, prevalente en todas las razas y que afecta principalmente a las poblaciones callejeras urbanas. Generalmente se manifiesta como masas en los órganos genitales externos, pero también puede aparecer en otras membranas mucosas por contacto directo. El tumor venéreo transmisible afecta predominantemente a perros de 2 a 5 años con alta actividad sexual; en los machos se localiza en el pene y el prepucio (6,66 %) (8/120), mientras que, en las hembras afecta la región vaginal posterior y la vulva (10 %) (12/120). El diagnóstico se basa en la historia clínica, la secreción crónica, la localización típica de las lesiones y las características histopatológicas confirmadas mediante tinción con Hematoxilina y Eosina. El análisis inmunohistoquímico utilizó desmina y miogenina para diferenciar las células del tumor venéreo transmisible y confirmar el diagnóstico. La quimioterapia con vincristina sigue siendo el tratamiento principal, a menudo combinada con cirugía.
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Crozet G. Naturally transmissible tumors: bibliographic synthesis [doctoral thesis on the Internet]. Maisons–Alfort (France): National Veterinary School of Alfort; 2018 [cited June 25, 2025]. 137 p. Available from: https://goo.su/bYnPdL
Ostrander EA, Davis BW, Ostrander GK. Transmissible tumors: breaking the cancer paradigm. Trends Genet. [Internet]. 2016; 32(1):1–15. doi: https://doi.org/f762ft DOI: https://doi.org/10.1016/j.tig.2015.10.001
Ugochukwu ICI, Agina OA, Omeke JN, Aneke CI, Adamu LF, Ajayi OL, Giginya NI, Ihedioha JI, Njoku CI, Sackey AKB. An appraisal of Canine transmissible venereal tumour with emphasis on molecular biology and pathology. Thai J. Vet. Med. [Internet]. 2025 [cited Apr. 12, 2025]; 50(1):1–12. Available from: https://goo.su/zeKFqE6 DOI: https://doi.org/10.56808/2985-1130.3069
Pimentel PAB, Giuliano A, Odatzoglou P, Ignatenko N, Wenceslau RR, Almeida IO, da Silva PHS, Costa MdP, Horta RS. Clinical guidelines for canine transmissible venereal tumour treatment: Systematic review and meta–analysis. Vet. Comp. Oncol. 2025; 23(2):125–140. doi: https://doi.org/pprn DOI: https://doi.org/10.1111/vco.13038
Oruç E, Sağlam YS, Cengiz M, Polat B. Bir Köpekte Bulaşıcı Venereal Tümör Meme Metastazının İnce İğne Aspirasyonu ile Sitolojik Teşhisi ve Vincristine Sülfat ile Tedavisi [Cytological diagnosis of breast metastasis of transmissible venereal tumor by fine needle aspiration and the treatment with vincristine sulfate in a dog]. Atatürk Üniversitesi Vet. Bilim. Derg. [Internet]. 2011 [cited Apr. 12, 2025]; 6(1):63–69. Turkish. Available from: https://goo.su/6NdEc
Laissaoui N, Millán Y, Simon Betz D, El Mrini M, Bouayad G, Lamalmi N, Tligui N, Azrib R. Canine transmissible venereal tumour in Morocco: Clinical and pathological findings in 64 dogs – insights from a descriptive epidemiological study (2020-2023). Open Vet. J. [Internet]. 2024; 14(5):1206–1215. doi: https://doi.org/pprp DOI: https://doi.org/10.5455/OVJ.2024.v14.i5.16
Bendas AJR, Moreto PLN, Coxo AB, Holguin PG, Soares DV. Intra–abdominal transmissible venereal tumor in a dog: a case report. Braz. J. Vet. Med. [Internet]. 2022; 44:e001422. doi: https://doi.org/p6nb DOI: https://doi.org/10.29374/2527-2179.bjvm001422
Da Silva DM, Oliveira MS, Franciosi AL, Belo CEP, Gonçalves KA, De Souza RS, Guérios SD. Treatment of canine transmissible venereal tumor using L–asparaginase, prednisone, and surgery in a clinical chemotherapy–resistant case. Turk. J. Vet. Anim. Sci. 2014; 38(2):220–223. doi: https://doi.org/p6nc DOI: https://doi.org/10.3906/vet-1309-23
Birhan G, Chanie M. A review on canine transmissible venereal tumor: from morphologic to biochemical and molecular diagnosis. Acad. J. Anim. Dis. 2015; [cited Apr. 13, 2025]; 4(3):185–195. Available from: https://goo.su/Z8lEXw
Castro KF, Strakova A, Tinucci–Costa M, Murchison EP. Evaluation of a 125 genetic assay for canine transmissible venereal tumour diagnosis in Brazil. Vet. Comp. Oncol. [Internet]. 2017; 15(2):615-618. doi: https://doi.org/f959mr DOI: https://doi.org/10.1111/vco.12205
Kumar A, Jadon NS, Zaidi MGH, Kandpal M, Saini R. Transmissible venereal granuloma invasiveness and response to chemotherapeutics in canine. Int. J. Contemp. Res. Multi. [Internet]. 2024; 3(3):140-147. doi: https://doi.org/p6rc
Amaral AS, Bassani–Silva S, Ferreira I, da Fonseca LS, de Andrade FH, Gaspar LFJ, Rocha NS. Cytomorphological characterization of transmissible canine venereal tumor. Rev. Port. Cienc. Vet. [Internet]. 2007 [cited Apr. 18, 2025]; 102(563–564):253–260. Available from: https://goo.su/X1r1d
Abedin SN. Canine transmissible venereal tumor: A review. J. Entomol. Zool. Stud. [Internet]. 2020; 8(2):596-599. doi: https://doi.org/p6nj
Den Otter W, Hack M, Jacobs JJL, Tan JFV, Rozendaal L, Van Moorselaar RJA. Effective treatment of transmissible venereal tumors in dogs with vincristine and IL-2. Anticancer Res. 2015 [cited Apr. 18, 2025]; 35(6):3385–3391. Available from: https://goo.su/vNlv
Sankar P, Ramya R, Mohamed Ali MG. Therapeutic management of intranasal transmissible venereal tumour in a dog. Intas. Polivet. 2016 [cited Apr. 18, 2025]; 17(2):543–545. Available from: https://goo.su/H3nFUU
Ganguly B, Das U, Das AK. Canine transmissible venereal tumour: A review. Vet. Comp. Oncol. [Internet]. 2016; 14(1):1–12. doi: https://doi.org/pprh DOI: https://doi.org/10.1111/vco.12060
Priyadarshini N, Das DP, Panda SK, Samal L. Transmissible venereal tumours (TVT) in bitches: A haematological, biochemical and histopathological study. J. Entomol. Zool. Stud. 2021; 9(1):490-493. doi: https://doi.org/p6pc DOI: https://doi.org/10.22271/j.ento.2021.v9.i1g.8194
Ke CH, Tomiyasu H, Lin YL, Huang WH, Huang HH, Chiang HC, Lin CS. Canine transmissible venereal tumour established in immunodeficient mice reprograms the gene expression profiles associated with a favourable tumour microenvironment to enable cancer malignancy. BMC Vet. Res. [Internet]. 2022; 18:4. doi: https://doi.org/p6pd
Murchison EP. Cancer: Transmissible tumours under the sea. Nature [Internet]. 2016; 534:628–629. doi: https://doi.org/p6pf DOI: https://doi.org/10.1038/nature18455
Morris K, Belov K. Does the devil facial tumour produce immunosuppressive cytokines as an immune evasion strategy? Vet. Immunol. Immunopathol. [Internet]. 2013; 153(1–2):159–164. doi: https://doi.org/p6pk DOI: https://doi.org/10.1016/j.vetimm.2013.02.008
Murchison EP, Wedge DC, Alexandrov LB, Fu B, Martincorena I, Ning Z, Tubio JMC, Werner EI, Allen J, de Nardi AB, Donelan EM, Marino G, Fassati A, Campbell PJ, Yang F, Burt A, Weiss RA, Stratton MR. Transmissible dog cancer genome reveals the origin and history of an ancient cell lineage. Science [Internet]. 2014; 343(6169):437–440. doi: https://doi.org/q7r DOI: https://doi.org/10.1126/science.1247167
Decker B, Davis BW, Rimbault M, Long AH, Karlins E, Jagannathan V, Reiman R, Parker HG, Drögemüller C, Corneveaux JJ, Chapman ES, Trent JM, Leeb T, Huentelman MJ, Wayne RK, Karyadi DM, Ostrander EA. Comparison against 186 canid whole–genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor. Genome Res. [Internet]. 2015; 25(11):1646–1655. doi: https://doi.org/f7xspm DOI: https://doi.org/10.1101/gr.190314.115
Siddle HV, Kreiss A, Tovar C, Yuen CK, Cheng Y, Belov K, Swift K, Pearse A–M, Hamede R, Jones ME, Skjødt K, Woods GM, Kaufman J. Reversible epigenetic down–regulation of MHC molecules by devil facial tumor disease illustrates immune escape by a contagious cancer. Proc. Natl. Acad. Sci. USA. [Internet]. 2013; 110(13):5103–5108. doi: https://doi.org/kr7 DOI: https://doi.org/10.1073/pnas.1219920110
Strakova A, Murchison EP. The changing global distribution and prevalence of canine transmissible venereal tumour. BMC Vet. Res. [Internet]. 2014; 10:168. doi: https://doi.org/f6fp4q DOI: https://doi.org/10.1186/s12917-014-0168-9
Ke CH, Tomiyasu H, Lin YL, Huang WH, Huang HH, Chiang HC, Lin CS. Canine transmissible venereal tumour established in immunodeficient mice reprograms the gene expression profiles associated with a favourable tumour microenvironment to enable cancer malignancy. BMC Vet. Res. [Internet]. 2022; 18(1):4. doi: https://doi.org/p6pd DOI: https://doi.org/10.1186/s12917-021-03093-4
Fonclara E, Goullet P. A case of canine transmissible venereal tumor in a young dog. Point Vet. 2017 [cited Apr. 18, 2025]; 48(377):12-15. Available from: https://goo.su/s6mqJbv
Baştan A, Acar DB, Cengiz M. Uterine and ovarian metastasis of transmissible venereal tumor in a bitch. Turk. J. Vet. Anim. Sci. 2008 [cited 18 Apr 2025]; 32(1):65–66. Available from: https://goo.su/vDB8bqk
Mirza U, Farooq UB, Makhdoomi DM. Canine transmissible venereal tumor: etiopathology, transmission and treatment. Asian J. Anim. Vet. Adv. [Internet]. 2022 [cited Apr. 12, 2025]; 17(2):39-43. Avaliable in: https://goo.su/fnNhB DOI: https://doi.org/10.3923/ajava.2022.39.43
Bandaranayaka BMLN, Kabilan S, Perera KARK, Abeykoon C, Wijewardena KAN, Ariyarathn HMS. Extragenital canine transmissible venereal tumours: A case series. Sri Lanka Vet. J. [Internet]. 2023; 70(1):27-32. doi: https://doi.org/p6rq DOI: https://doi.org/10.4038/slvj.v70i1.73
do Prado Duzanski A, Flórez LMM, Fêo HB, Romagnoli GG, Kaneno R, Rocha NS. Cell–mediated immunity and expression of MHC class I and class II molecules in dogs naturally infected by canine transmissible venereal tumor: Is there complete spontaneous regression outside the experimental CTVT? Res. Vet. Sci. [Internet]. 2022; 145:193-204. doi: https://doi.org/p6rv DOI: https://doi.org/10.1016/j.rvsc.2022.02.020
Aydın İ, Bülbül A, Avcı GE, Celik HA. Serum oxidative status and adenosine deaminase activity in dogs with transmissible venereal tumour. Bull. Vet. Inst. Pulawy [Internet]. 2009 [cited Apr. 18, 2025]; 53:771–774. Available from: https://goo.su/tcUWs
Blanca PM, María Luisa FR, Guadalupe M, Fátima CL. Oxidative stress in canine diseases: A comprehensive review. Antioxidants. [Internet]. 2024; 13(11):1396. doi: https://doi.org/p6rw. DOI: https://doi.org/10.3390/antiox13111396
Küçükbekir CN, Günay Uçmak Z, Tek C. Canine transmissible venereal tumor: Etiology, diagnosis, and treatment. J. Istanbul Vet. Sci. [Internet]. 2021; 5(1):57-65. doi: https://doi.org/p6p7 DOI: https://doi.org/10.30704/http-www-jivs-net.882280
Simoni R, Knoll JC. Clinical Exposures: Canine transmissible venereal tumor – the cytologic clues. Vet. Med. [Internet]. 2008 [cited Apr. 18, 2025]; 103(6):296-304. Available from: https://goo.su/cSYqdYC
Baez–Ortega A, Gori K, Strakova A, Allen JL, Allum KM, Bansse– Issa L, Bhutia TN, Bisson JL, Briceño C, Castillo Domracheva A, Corrigan AM, Cran HR, Crawford JT, Davis E, de Castro KF, de Nardi AB, de Vos AP, Delgadillo Keenan L, Donelan EM, Espinoza Huerta AR, Faramade IA, Fazil M, Fotopoulou E, Fruean SN, Gallardo–Arrieta F, Glebova O, Gouletsou PG, Häfelin Manrique RF, Henriques JJGP, Horta RS, Ignatenko N, Kane Y, King C, Koenig D, Krupa A, Kruzeniski SJ, Kwon Y–M, Lanza–Perea M, Lazyan M, Lopez Quintana AM, Losfelt T, Marino G, Martínez Castañeda S, Martínez–López MF, Meyer M, Migneco EJ, Nakanwagi B, Neal KB, Neunzig W, Ní Leathlobhair M, Nixon SJ, Ortega–Pacheco A, Pedraza–Ordoñez F, Peleteiro MC, Polak K, Pye RJ, Reece JF, Rojas Gutierrez J, Sadia H, Schmeling SK, Shamanova O, Sherlock AG, Stammnitz M, Steenland–Smit AE, Svitich A, Tapia Martínez LJ, Thoya Ngoka I, Torres CG, Tudor EM, van der Wel MG, Viţălaru BA, Vural SA, Walkinton O, Wang J, Wehrle–Martinez AS, Widdowson SAE, Stratton MR, Alexandrov LB, Martincorena I, Murchison EP. Somatic evolution and global expansion of an ancient transmissible cancer lineage. Science [Internet]. 2019; 365(6452): eaau9923. doi: https://doi.org/gg6qqw DOI: https://doi.org/10.1126/science.aau9923
Cohen D. The canine transmissible venereal tumor: a unique result of tumor progression. Adv. Cancer Res. [Internet]. 1985; 43:75–112. doi: https://doi.org/dr42n9 DOI: https://doi.org/10.1016/S0065-230X(08)60943-4
Martins MIM, Souza FF, Gobello C. The canine transmissible venereal tumor: etiology, pathology, diagnosis and treatment. Adv. Small Anim. Reprod. [Internet]. 2005 [cited Apr. 18, 2025]; 25-32. Available from: https://goo.su/1cCo1
Kennedy JR, Yang TJ, Allen PL. Canine transmissible venereal sarcoma: electron microscopic changes with time after transplantation. Br. J. Cancer. [Internet].1977; 36(3):375–385. doi: https://doi.org/b9z6k2 DOI: https://doi.org/10.1038/bjc.1977.203
Marchal T, Chabanne L, Kaplanski C, Rigal D, Magnol JP. Immunophenotype of the canine transmissible venereal tumour. Vet. Immunol. Immunopathol. [Internet]. 1997; 57(1–2):1–11. doi: https://doi.org/b3sctw DOI: https://doi.org/10.1016/S0165-2427(96)05757-1
Lorimier LP, Fan TM. Canine transmissible venereal tumor. In: Withrow SJ, Vail DM, Page RL, editors. Withrow and MacEwen’s Small Animal Clinical Oncology. 4th ed. 2007; St. Louis (USA): Saunders Elsevier. p. 799–804.
McEntee MC. Reproductive oncology. Clin. Tech. Small Anim. Pract. [Internet]. 2002; 17(3):133–149. doi: https://doi.org/cw75kj DOI: https://doi.org/10.1053/svms.2002.34642
Den Otter W, Hack M, Jacobs JJL., Tan JFV, Rozendaal L, Van Moorselaar JA. Effective treatment of transmissible venereal tumors in dogs with vincristine and IL2. Anticancer Res. 2015 [cited Apr. 18, 2025]; 35(6):3385–3391. PMID: 26026076. Available from: https://goo.su/ozWbc8
Souza JRST, Camarão AP, Rego LC. Ruminal degradability of dry matter and crude protein of agroindustry, fish and slaughterhouse byproducts in goats. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2000 [cited Apr. 18, 2025]; 37(2):144–150. Available from: https://goo.su/UmBIe DOI: https://doi.org/10.1590/S1413-95962000000200015
Stockmann D, Ferrari HF, Andrade AL, Lopes RA, Cardoso TC, Luvizotto MCR. Canine transmissible venereal tumors: Aspects related to programmed cell death. Braz. J. Vet. Pathol. [Internet]. 2011 [cited Apr. 18, 2025]; 4(1):67–75. Available from: https://goo.su/CU8C
MacLachlan NJ, Kennedy PC. Tumors of the genital systems. In: Meuten DJ, editor. Tumors in Domestic Animals, 4th ed. Iowa (USA): Iowa State Press. 2002; p. 547–573. DOI: https://doi.org/10.1002/9780470376928.ch11
Veloso JF, Oliveira TN, Andrade LP, Silva FL, Sampaio KMOR., Michel AFRM, Lavor MSL, Carlos RSA. Three cases of exclusively extragenital canine transmissible venereal tumor (cTVT). Acta Sci. Vet. [Internet]. 2018; 46:8. doi: https://doi.org/p6p8 DOI: https://doi.org/10.22456/1679-9216.86846
Boyé P, Benoit J. Les tumeurs vénériennes transmissibles canines. Le Point Vétérinaire Expert Canin. 2016 [cited Apr. 18, 2025]; 364. Available from: https://goo.su/iupehA
Liptak JM, Christensen NI. Soft tissue sarcomas. In: Vail DM, Thamm DH, Liptak JM, editors. Withrow & MacEwen’s Small Animal Clinical Oncology. 6th ed. 2019; New York (USA): Saunders, p. 404–431. DOI: https://doi.org/10.1016/B978-0-323-59496-7.00022-0
Rogers KS, Wantschek L, Lees GE. Diagnostic evaluation of the canine prostate. Compend. Contin. Educ. Pract. Vet. 1986; 8(11):799–811.
Morgan E, O’Riordan RM, Kelly TC, Culloty SC. Influence of disseminated neoplasia, trematode infections and gametogenesis on surfacing and mortality in the cockle Cerastoderma edule. Dis. Aquat. Organ. 2012; 98(1):73–84. doi: https://doi.org/fg4j66 DOI: https://doi.org/10.3354/dao02428
Amrutha VS, Rajimon KT, Prakash AK, Viswanathan CK, Sulabha G, Jithil VR. Therapeutic management of canine transmissible venereal tumor associated Phimosis in a dog. Int. J. Vet. Sci. Anim. Husb. [Internet]. 2023 [cited Apr. 22, 2025]; 8(5):467-469. https://goo.su/PU3C4aR
Tella MA, Ajala OO, Taiwo VO. Complete regression of transmissible venereal tumour (TVT) in Nigerian mongrel dogs with vincristine sulfate chemotherapy. Afr. J. Biomed. Res. 2004; 7(3):133–138. doi: https://doi.org/b83bbh DOI: https://doi.org/10.4314/ajbr.v7i3.54172
 
											 
							













