Efectos antioxidantes y de cicatrización de heridas de la consuelda (Symphytum officinale)
Resumen
Este estudio exploró los efectos de la consuelda (Symphytum officinale) en el tratamiento de quemaduras de tercer grado en un modelo de ratas, demostrando resultados prometedores. Se crearon quemaduras estandarizadas con un hierro caliente, después de lo cual tres grupos de ratas recibieron diferentes tratamientos: sin tratamiento (control), vaselina o una pomada con un 20% de consuelda. Las evaluaciones histopatológicas tanto a los 7 como a los 14 días mostraron una curación acelerada en el grupo tratado con consuelda en comparación con el grupo control, lo que indica el potencial de la consuelda para mejorar la recuperación de las heridas. Además, se evaluó la capacidad antioxidante de la consuelda utilizando ensayos como el poder reductor de Fe³+ y Cu²+ y las actividades de scavenging de radicales libres (ensayos DPPH· y ABTS•+). Los valores de IC50 para la eliminación de DPPH· fueron 69,30 µg·mL-1 (extracto acuoso) y 46,20 µg·mL-1, mientras que para la eliminación de ABTS•+ fueron 77,00 µg·mL-1 y 69,30 µg·mL-1 (extracto etanólico). Estos resultados confirman que la consuelda exhibe una actividad antioxidante significativa, lo que probablemente contribuye a sus propiedades de cicatrización de heridas. En general, este estudio sugiere la consuelda como una opción segura de tratamiento tradicional para la curación de quemaduras, con beneficios que probablemente provienen de su actividad antioxidante. Los resultados sugieren que esta combinación es una medicina tradicional segura para aplicaciones clínicas en dosis adecuadas.
Descargas
Citas
Demie G, Negash M, Awas T. Ethnobotanical study of medicinal plants used by indigenous people in and around Dirre Sheikh Hussein heritage site of South–eastern Ethiopia. J. Ethnopharmacol. [Internet]. 2018; 220:87–93. doi: https://doi.org/gn6cxv
Ozgokce F, Ozcelik H. Ethnobotanical aspects of some taxa in east Anatolia, Turkey. Econ. Bot. [Internet]. 2004; 58:697–704. doi: https://doi.org/fkw5zx
Polat Köse L, Gulcin I, Goren AC, Namiesnik J, Martinez–Ayala AL, Gorinstein S. LC–MS/MS analysis, antioxidant and anticholinergic properties of galanga (Alpinia officinarum Hance) rhizomes. Ind. Crops Prod. [Internet]. 2015; 74:712–721. doi: https://doi.org/n875
Tohma H, Gulcin I, Bursal E, Goren AC, Alwasel SH, Koksal E. Antioxidant activity and phenolic compounds of ginger (Zingiber officinale Rosc.) determined by HPLC–MS/MS. J. Food Meas. Charact. [Internet]. 2017; 11:556–566. doi: https://doi.org/gp63n3
Oktay M, Gulcin I, Kufrevioglu OI. Determination of in vitro antioxidant activity of fennel (Foeniculum vulgare) seed extracts. LWT – Food Sci. Technol. [Internet]. 2003; 36(2):263–271. doi: https://doi.org/csnbc6
Gulcin I, Mshvildadze V, Gepdiremen A, Elias R. Screening of antiradical and antioxidant activity of monodesmosides and crude extract from Leontice smirnowii tuber. Phytomedicine. [Internet]. 2006; 13(5):343–351. doi: https://doi.org/cbkmfr
Gulcin I, Elmastas M, Aboul–Enein HY. Antioxidant activity of clove oil – A powerful antioxidant source. Arab. J. Chem. [Internet]. 2012; 5(4):489–499. doi: https://doi.org/dgf58p
Staiger C. Comfrey: A clinical overview. Phytother. Res. [Internet]. 2012; 26(10):1441–1448. doi: https://doi.org/gfrmx8
Asimgil A. Şifalı Bitkiler [Medicinal herbs]. İstanbul (Türkiye): Timaş Publications; 2009. 317 p. Turkish
Zor F, Ersoz N, Kulahci Y, Kapi E, Bozkurt M. Gold standards for primary care of burn management. Dicle Med. J. [Internet]. 2009 [cited 24 Sep. 2024]; 36(3):219–225. Available in: https://goo.su/iSZV
Peck MD. Epidemiology of burns throughout the world. Part I: Distribution and risk factors. Burns [Internet]. 2011; 37(7):1087–1100. doi: https://doi.org/dhhwhn
Patel PP, Vasquez SA, Granick MS, Rhee ST. Topical antimicrobials in pediatric burn wound management. J. Craniofac. Surg. [Internet]. 2008; 19(4):913–922. doi: https://doi.org/b74q5d
Broussard KC, Powers JG. Wound dressings: Selecting the most appropriate type. Am. J. Clin. Dermatol. [Internet]. 2013; 14:449–459. doi: https://doi.org/f5hk8g
Mulder GD, Cavorsi JP, Lee DK. Polyhexamethylene Biguanide (PHMB): An addendum to current topical antimicrobials. Wounds [Internet]. 2007 [cited 24 Sep. 2024]; 19(7):173-182.Available in: https://goo.su/7KXemvw
Sahin S, Saygun I, Kurt B, Canakci FC, Akyol M, Altug HA, Kurtis B, Sencimen M. Lokal antimikrobiyal ajanların palatinal bölgeden alınan greft alanındaki doku defektinin iyileşmesi üzerine etkilerinin histomorfometrik yöntemle incelenmesi [The histomorphometrical evaluation of the effects of local antimicrobial agents in the healing of the tissue defect in the graft area obtained from the palatinal region]. Gülhane Tip Dergisi [Internet]. 2009 [cited 22 Oct. 2024]; 51:27–33. Turkish. Available in: https://goo.su/4In8K
Panda A, Ahuja R, Biswas NR, Satpathy G, Khokhar S. Role of 0.02% polyhexamethylene biguanide and 1% povidone iodine in experimental Aspergillus keratitis. Cornea [Internet]. 2003; 22(2):138–141. doi: https://doi.org/fh62dq
Slinkard K, Singleton VL. Total phenol analysis: Automation and comparison with manual methods. Am. J. Enol. Viticult. [Internet]. 1977; 28:49–55. doi: https://doi.org/n88r
Topal F, Nar M, Gocer H, Kalin P, Kocyigit UM, Gulcin I. Antioxidant activity of taxifolin: an activity–structure relationship. J. Enzyme Inhib. Med. Chem. [Internet]. 2016; 31(4):674–683. doi: https://doi.org/gmpv5f
Koksal E, Bursal E, Gulcin I, Korkmaz M, Caglayan C, Goren AC, Alwasel SH. Antioxidant activity and polyphenol content of Turkish thyme (Thymus vulgaris) monitored by liquid chromatography and tandem mass spectrometry. Int. J. Food Propert. [Internet]. 2017; 20(3):514–525. doi: https://doi.org/gnbhvf
Tohma H, Koksal E, Kilic O, Alan Y, Yilmaz MA, Gulcin I, Bursal E, Alwasel SH. RP–HPLC/MS/MS analysis of the phenolic compounds, antioxidant and antimicrobial activities of Salvia L. species. Antioxidants [Internet]. 2016; 5(4):38. doi: https://doi.org/n88s
Blois MS. Antioxidant determinations by the use of a stable free radical. Nature. 1958 [cited 22 Jun. 2024]; 181:1199–1200. Available in: https://goo.su/Gh5RW9U
Oztaskin N, Taslimi P, Maras A, Gulcin I, Goksu S. Novel antioxidant bromophenols with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions. Bioorg. Chem. [Internet]. 2017; 74:104–114. doi: https://doi.org/gb4gd2
Huyut Z, Beydemir S, Gulcin I. Antioxidant and antiradical properties of some flavonoids and phenolic compounds. Biochem. Res. Int. [Internet]. 2017; 2017:7616791. doi: https://doi.org/gcknft
Han H, Yilmaz H, Gulcin I. Antioxidant activity of flaxseed (Linum usitatissimum L.) and analysis of its polyphenol contents by LC–MS/MS. Rec. Nat. Prod. [Internet]. 2018; 12(4):397–402. doi: https://doi.org/n88v
Taslimi P, Gulcin I. Antioxidant and anticholinergic properties of olivetol. J. Food Biochem. [Internet]. 2018; 42:1–11. doi: https://doi.org/gds2nf
Akhoondinasab MR, Khodarahmi A, Akhoondinasab M, Saberi M, Iranpour M. Assessing effect of three herbal medicines in second and third degree burns in rats and comparison with silver sulfadiazine ointment. Burns [Internet]. 2015; 41(1):125–131. doi: https://doi.org/f6xt9k
Sehitoglu MH, Han H, Kalin P, Gulcin I, Ozkan A, Aboul–Enein HY. Pistachio (Pistacia vera L.) Gum: A potent inhibitor of reactive oxygen species. J. Enzyme Inhib. Med. Chem. [Internet]. 2015; 30(2):264–269. doi: https://doi.org/n88z
Bursal E, Köksal E, Gulcin I, Bilsel G, Goren AC. Antioxidant activity and polyphenol content of cherry stem (Cerasus avium L.) determined by LC–MS/MS. Food Res. Int. [Internet]. 2013; 51(1):66–74. doi: https://doi.org/f4s6jk
Gulcin I. Antioxidant activity of food constituents–An overview. Arch. Toxicol. [Internet]. 2012; 86:345–391. doi: https://doi.org/b6xz48
Elmastas M, Gulcin I, Isildak O, Kufrevioglu OI, Ibaoglu K, Aboul–Enein HY. Antioxidant capacity of bay (Laurus nobilis L.) leaves extracts. J. Iran. Chem. Soc. 2006; 3(3):258–266. doi: https://doi.org/n884
Bass H, Moore JL, Coakley WT. Lethality in mammalian cells due to hyperthermia under oxic and hypoxic conditions. Int. J. Rad. Biol. [Internet]. 1978; 33(1):57–67. doi: https://doi.org/c553v2
Polat Y, Karabulut A, Balci IY, Cilengir M, Ovet G, Cebelli S. Evaluation of culture and antibiogram results in burned patients. Pamukkale Med. J. [Internet]. 2010 [cited 24 Sep. 2024]; 3:131–135. Available in: https://goo.su/P9bISX
Bayram Y, Yildirim AO, Eyi E. Yanıkta Acil, Acilde Yanık [Emergency in burn, burn in emergency]. TAF Prev. Med. Bull. [Internet]. 2012; 11(3):365–368. Turkish. doi: https://doi.org/n89d
Brusselaers N, Monstrey S, Vogelaers D, Hoste E, Blot S. Severe burn injury in europe: a systematic review of the incidence, etiology, morbidity, and mortality. Crit. Care [Internet]. 2010; 14:R188. doi: https://doi.org/c97w3j
Herndon DN, Spies M. Modern burn care. Semin. Pediatr. Surg. [Internet]. 2001; 10(1):28–31. doi: https://doi.org/c445g3
Atiyeh BS, Gunn SW, Hayek SN. State of the Art in burn treatment. World J. Surg. [Internet]. 2005; 29(2):131–148. doi: https://doi.org/dbqdsc
Pruitt BA Jr, McManus AT, Kim SH, Goodwin CW. Burn wound infections: current status. World J. Surg. [Internet]. 1998; 22(2):135-145. doi: https://doi.org/cvnzc2
Sindak N, Akgul MB, Gulaydin A, Karakoc Z. Japon Bıldırcınlarında (Coturnix Coturnix Japonica) Topikal Olarak Uygulanan Menengiç Yağı ve Farklı Deneysel Karışımlarının Yara İyileşmesi Üzerine Etkileri [Effects of topical terebinth berry oil and different experimental mixtures on wound healing in Japanese quails (Coturnix Coturnix Japonica)]. Van Vet. J. [Internet]. 2017 [Cited 23 Aug. 2024]; 28(2):69–74. Turkish. Available in: https://goo.su/8O2XY
Yildiz Y, Gul S, Yakan S. Investigation of effects of essential oils of Cumin (Cuminum cyminum) and Wild Thyme (Thymbra spicata) on human lymphocyte chromosomes. East. Anatol. J. Sci. 2015 [cited 23 Sep. 2024]; 1(2):87–97. Available in: https://goo.su/pf9K
Pazyar N, Yaghoobi R, Rafiee E, Mehrabian A, Feily A. Skin wound healing and phytomedicine: a review. Skin Pharmacol. Physiol. [Internet]. 2014; 27(6):303–310. doi: https://doi.org/f6cf37
Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Konqkaew C. The efficacy of aloe vera used for burn wound healing: A systematic review. Burns [Internet]. 2007; 33(6):713–718. doi: https://doi.org/c4c8zz
Hosseinimehr SJ, Khorasani G, Azadbakht M, Zamani P, Ghasemi M, Ahmadi A. Effect of Aloe cream versus silver sulfadiazine for healing burn wounds in rats. Acta Dermatovenerol Croat. 2010; 18(1):2–7. PMID: 20361881.
Singh M, Singh S, Nath V, Sahu V, Rawat AKS. Antibacterial activity of some bryophytes used traditionally for the treatment of burn infections. Pharm. Biol. [Internet]. 2011; 49(5):526–530. doi: https://doi.org/bw99s6
Suboj P, Babykutty S, Valiyaparambil Gopi DR, Nair RS, Srinivas P, Gopala S. Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF–kB. Eur. J. Pharm. Sci. [Internet]. 2012; 45(5):581–591. doi: https://doi.org/fx2fc5
Altan A, Damlar I, Aras MH, Alpaslan C. Effect of St. John’s Wort (Hypericum perforatum) on wound healing. Arch. Med. Rev. J. [Internet]. 2015; 24(4):578–591. doi: https://doi.org/n89j
Martinez–Poveda B, Quesada AR, Medina MA. Hypericin in the dark inhibits key steps of angiogenesis in vitro. Eur. J. Pharmacol. [Internet]. 2005; 516(2):97–103. doi: https://doi.org/dmmk74
Spin–Neto R, Belluci MM, Sakakura CE, Scaf G, Pepato MT, Marcantonio E. Homeopathic Symphytum officinale increases removal torque and radiographic bone density around titanium implants in rats. Homeopathy [Internet]. 2010; 99(04):249–254. doi: https://doi.org/b9mrpk
Smith DB, Jacobson BH. Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo–controlled, double–blind, multiclinical trials. J. Chiropr. Med. [Internet]. 2011; 10(3):147–156. doi: https://doi.org/d82dww
Mulkijanyan K, Barbakadze V, Novikova Z, Sulakvelidze M, Gogilashvili L, Amiranashvili L, Merlani M. Burn healing compositions from caucasian species of comfrey (Symphytum L.). Bull. Georg. Natl. Acad. Sci. [Internet]. 2009 [cited 12 Sep. 2024]; 3(3):114–117. Available in: https://goo.su/290zDxm
Derechos de autor 2025 Selvinaz Yakan, Yusuf Kenan Dağlıoğlu, Kıvılcım Eren Erdoğan, Rüya Sağlamtaş, İlhami Gülçin
Esta obra está bajo licencia internacional Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0.
